Development in the Drug Delivery Tools that Transport Medically Active Biomolecules
- Open Access Journal of Science
- Sheshanath V Bhosale, RMIT University, Australia
The drug-delivery tool that transport medically active molecules to diseased cells, in a precise manner, have grew much consideration in past decades. Supramolecular self-assembled systems plays an important role in nanotechnology, biotechnology, and regenerative medicine .Based on self-assembly approach various drug-delivery systems have been developed for example polymers, micelles, vesicles,nanoparticles  and vesicular-supported particles .Among these developed systems, silica particles based delivery tool have become popular as biocompatible alternatives . Most sophisticated mesoporous silica nanoparticle (MSNs) have widely used  due to their applicability to release drug molecule in controlled in particular cells using internal stimuli, such as pH and enzymes or external stimuli such as light,  redox properties and temperature . The most discovered approaches to controlled drug-release were based on MSN carriers through surface functionalisation, with biomolecule responsive gates, pH- or photo-triggered release from hollow MSN . However, these methods are challenging, and suffer from limitations due to the low tissue-penetration-depth of light .
Yoctowells, Transport system, Supramolecular, Drug delivery, Nanoparticles, Biological, Fluorescence spectroscopy, Absorption, in vivo, Supramolecular, Medicine