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Development in the Drug Delivery Tools that Transport Medically Active Biomolecules


Open Access Journal of Science
Sheshanath V Bhosale, RMIT University, Australia

Abstract

The drug-delivery tool that transport medically active molecules to diseased cells, in a precise manner, have grew much consideration in past decades. Supramolecular self-assembled systems plays an important role in nanotechnology, biotechnology, and regenerative medicine [1].Based on self-assembly approach various drug-delivery systems have been developed for example polymers,[2] micelles,[3] vesicles,[4]nanoparticles [5] and vesicular-supported particles [6].Among these developed systems, silica particles based delivery tool have become popular as biocompatible alternatives [7]. Most sophisticated mesoporous silica nanoparticle (MSNs) have widely used [8] due to their applicability to release drug molecule in controlled in particular cells using internal stimuli, such as pH[9] and enzymes[10] or external stimuli such as light, [11] redox properties [12]and temperature [13]. The most discovered approaches to controlled drug-release were based on MSN carriers through surface functionalisation, with biomolecule responsive gates, pH- or photo-triggered release from hollow MSN [14]. However, these methods are challenging, and suffer from limitations due to the low tissue-penetration-depth of light [15].

Keywords

Yoctowells, Transport system, Supramolecular, Drug delivery, Nanoparticles, Biological, Fluorescence spectroscopy, Absorption, in vivo, Supramolecular, Medicine

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