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Necrotizing Autoimmune Myopathy; an Emerging Entity in the Spectrum of Inflammatory Myopathies

Journal of Lung, Pulmonary & Respiratory Research
Mohammad Shariq Mukarram, Jinnah Medical College Hospital, Pakistan


1.1.Background: Necrotizing autoimmune myopathy is a relatively newly recognized rare form of idiopathic inflammatory myopathy. It presents clinically with symmetrical proximal muscle pain and weakness, associated with a markedly elevated Creatine kinase. These myopathies are usually immune mediated with a good response to immunotherapy.

1.2.Case presentation: We present a case of a 52 year old man of Asian descent, who presented with a 5 month history of symmetrical proximal muscle weakness. Patient underwent extensive workup and was diagnosed as having Necrotizing autoimmune myopathy with characteristic findings on muscle biopsy and positive HMGCR antibodies.

1.3.Conclusion:The disease process of Necrotizing autoimmune myopathy is still not completely understood. A delay in diagnosis may however lead to potential complications as the disease progresses rapidly.


Myopathy, Rheumatology, Proximal interphalangeal, Biochemistry, Hematology, Immunosuppressant drugs, Metacarpophalangeal, Metacarpo, Straight leg raise, Adenocarcinomas