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CRISPR technology challenge facing the numerical integrity of whole human genome DNA 


MOJ Biology and Medicine
Jean-Claude Perez
Retired interdisciplinary researcher (IBM), France

Abstract

Background: Global analysis of 3 human genomes of increasing levels of evolution (Neanderthal / Sapiens Build34 / Sapiens hg38) reveals 2 levels of numerical constraints controlling, structuring and optimizing these genome's DNA sequences. A global constraint - called "HGO" for "Human Genome Optimum" - optimizes the genome at its global scale. The same operator applied to each of the 24 individual chromosomes reveals a hierarchical structure of these 24 chromosomes.

Results:Then analysing the single strand DNA CG / TA proportions at whole chromosomes and genome scale reveals strong fine-tuned numerical ratios evidencing the "closure" nature (Varela's autopoiesis theory) of whole human genome.

Keywords

Human genome, CRISPR, Biomathematics, Evolution, Autopoiesis, DNA CG, Hierarchical spectrum, HGOs, Living systems, Biologist Francisco, Center of gravity, Amplitude, Numerical unit, Autonomous, Integrity, Mechanism, Error calculations

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