Abstract

Background & Aim: Chronic lymphocytic leukemia (CLL) is the most common lymphoid leukemia in Western Countries. Also, in Asian countries, such as Iran is expanding. This study was investigated in Kermanshah province in 73 patients newly diagnosed with chronic lymphocytic leukemia, and the aim of this paper is the evaluation of overall survival (OS) rate and the factors affecting it.
Methods and material: This is a descriptive-cross sectional study on 73 patients with CLL during 1998-2016 and patients were classified according to clinical symptoms, age’s mean, sex, laboratory findings, diagnostic tests, the therapeutic regimens and side effects from them. Data were entered into SPSS, CAN-Reg4 and all tests were performed at the 5% level of significance using SPSS version 17.0. Patients with CLL have referred to related clinical oncologist have been evaluated in our paper from Kermanshah province during 18 years.
Results: According to our findings from this study the mean age of the patients at diagnosis was 59.58 years that 53.4 % were male. Mean of OS in patients was 175.53 months, in a detail, mean of survival in 39 male patients was 128.52 months and in 34 female patients was 190.66 months. Also, OS was associated with the stage of disease (CLL), sex and treatment. The 5-year survival and the ten-year survival rate of patients were 89% and 81%, respectively.
Conclusion: According to recently progression in CLL treatment, but this malignancy still incurable and this is an important point for the evaluation of survival rate in this patients. Based on our findings in addition to significantly increasing in OS, related factors also are important and efficient on OS.

Keywords

Chronic, Lymphocytic, Leukemia, Overall Survival, Chronic Lymphocytic Leukemia, Descriptive-cross sectional study, SPSS, CAN-Reg4, Hematology-oncology, Laboratory findings,Treatment protocol, Flow Cytometry, Cytogenetic, Chemotherapy Regimen