Abstract

The aim of the study was to study the effect of L-arginine on the content of certain interleukins in the exhaled air condensate (CVC) in patients with bronchial asthma. 52 patients with a persistent asthma of a moderate course were examined. Two groups were formed. Patients of the main group (26), in addition to the standard basic therapy, received a nitric oxide donor - L-arginine. The comparison group (26) received only basic therapy. In patients of both groups before and after treatment, certain parameters of the immune system (IL-4, TNF-α) were measured in CMV. The initial data in patients of both groups were characterized by an increase in IL-4 and TNF-α in KVV compared with the group of healthy individuals. The content of IL-4 and TNF-α in KVB against the background of L-arginine significantly decreased during the control period. Changes in these parameters in the control group were not so pronounced and were unreliable. The inclusion of L-arginine in the baseline therapy contributed to an earlier and significant decrease in the content of the studied interleukins.

Keywords

Bronchial asthma, L-arginine, Interleukins, Endothelial dysfunction, Exhaled air condensate, IL-4, TNF-?, KVV, CMV, CVC, Air condensate, Baseline therapy, Asthma, Endothelium, Disease