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Evaluation of toxicological and behavioral symptoms on deltamethrin treated albino rats


MOJ Anatomy & Physiology
Anil Kumar
Department of Anatomy and Neurobiology, Oman Medical College, Oman

Abstract

Background: Pesticides are one of the most alarming toxic substances that are deliberately added to our environment. Deltamethrin, a Type-II synthetic pyrethroid used to control a variety of insects in agriculture and domestic environments. Its extensive commercial use has lead to inescapable concern over the potential adverse effects on the human health. The present study investigated the deleterious effects on behavior in albino rats, including motor coordination abilities and overall activity.

Methods: Deltamethrin was administered intraperitoneal in adult wistar albino rats (250-270 gm), in the dose of 0.5 mg/kg/ body weight for a month. All rats were observed for behavioral and toxicological symptoms. Body weight and rectal temperature were measured. The open field behavior, social interaction test, landing foot splay, and forelimb and hindlimb grip test for neuromuscular function were done.

Result: Experimental rats showed sign of mild to moderate variety of behavior and toxicological symptoms characterized by decreased food intake and salivation, motor incoordination, looping, weaving etc. Deltamethrin treated rats showed statistical significant decrease in body weight. There was decreased locomotor and rearing frequency but increased duration of immobility. The social interaction was decreased and large foot angle was seen in treated rats. Delayed onset of reflexes was also observed.

Conclusion: The present study, thus, shows a great deal of variability in the toxicity and motor coordination in deltamethrin exposed rats.

Keywords

deltamethrin, pyrethroids, insecticides, behavior pattern, open field behavior, social interaction test, landing foot splay, motor coordination, toxicity, amino butyric acid, choreoathetosis, indiscriminate, lethality, arbitrarily, rearing frequency

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