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Therapeutic management of intoxication with sodium fluoracetate (matarratas guayaquil®) and sodium monoacetate (matarratas sicario®) in caninos, medellín, colombia (2015-2018)


MOJ Toxicology
Víctor Manuel Molina Díaz
Lasallian University Corporation, Colombia

Abstract

Report on the therapeutic management of intoxication with fluoracetate and sodium monoacetate in canines, in Medellín, Colombia, between the years 2015 to 2018. Thirty canine patients, who came to consultation with neurological symptoms, dysphoria and convulsion, of one hour of evolution, All the animals came into contact with sodium fluoracetate (Guayaquil® rat poison) or sodium monoacetate (Sicario® rat poison), orally. All were subjected to a management protocol, with canalization of external cephalic vein, ringer lactate solution (Hartman), seizure control with intravenous pentobarbital 10mg/kg, initial dose, then intubated, in addition received: ethanol 28% 10ml/kg diluted in Hartman, calcium gluconate 1mg/kg in infusion and glyceryl guayacolate in slow intravenous 110mg/kg. All the patients were evaluated in their physiological constants and neurological status, according to the Glasgow scale. Protocol was maintained until the absence of convulsive signs, dysphoria and delirium. Thirty patients survived intoxication, the average recovery was 3days, it was not possible to determine the presence of sequelae after intoxication, patients received medical control 20days later. Neurological sequelae could not be determined. Timely management of the toxic condition, with anticonvulsants, alkalizing solutions, calcium gluconate, glyceryl guaiacolate and ethanol, proved to be effective strategies for the management of poisoning by sodium fluoracetate or sodium monoacetate.

Keywords

convulsion, delirium, rodenticides, toxic, aconitase, fluorocytrate, pyruvic acid, animal species, enzyme, calcium gluconate, monoacetate, sodium, fluoracetate, Adenyl, triphosphate

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