The antioxidant effect of Brazil nut (Bertholletia excelsa) is influenced by a genetic superoxide-hydrogen peroxide imbalance in healthy humans
- Journal of Nutritional Health & Food Engineering
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Ivana Beatrice Mânica da Cruz,1,2,3 Jéssica de Rosso Motta,1 Adriano Flesch Lenz,1 Thamara Graziela Flores,2 Fernanda Barbisan,2 Verônica Farina Azzolin,3 Maiquidieli Dal Berto,4 Alencar Kolinski Machado,5 Ednea Aguiar Maia Ribeiro,6 Euler Esteves Ribeiro6
Graduate Program in Gerontology, Federal University of Santa Maria, Brazil - Ivana Beatrice M, Morphology Department, Federal University of Santa Maria, Brazil
- J, Morphology Department, Federal University of Santa Maria, Brazil
- Adriano Flesch Lenz, Morphology Department, Federal University of Santa Maria, Brazil
- Thamara Graziela Flores, Graduate Program in Gerontology, Federal University of Santa Maria, Brazil
- Ver, Graduate program of Pharmacology, Federal University of Santa Maria, Brazil
- Maiquidieli Dal Berto, Graduate Program in Pathology, Federal University of Health Sciences of Porto Alegre, Brazil
- Alencar Kolinski Machado, Franciscan University Center, Brazil
- Ednea Aguiar Maia Ribeiro, Open University of the Third Age, State University of Amazonas, Brazil
- Euler Esteves Ribeiro, Open University of the Third Age, State University of Amazonas, Brazil
Abstract
Some plants are rich in a specific antioxidant that has a glutathione peroxidase -like effect, such as Brazil nut (BN) (Bertholletia excelsa), rich in selenium. This effect could be relevant to human health among people with a genetic superoxide anion-hydrogen peroxide (SA-HP) imbalance caused by a single nucleotide polymorphism located in the gene of manganese-dependent superoxide dismutase (Val16Ala-SOD2, rs4880). The AA genotype results in higher SOD2 levels leading to an increase in hydrogen peroxide levels related to a risk of some cancers. Because there evidence suggesting that habitual consumption of fruits and vegetables can minimize this risk, we hypothesized that BN is beneficial to subjects with genotype AA by decreasing the basal SA-HP imbalance. We performed an analysis of the acute antioxidant effect of one-time ingestion of 10 g of BN among healthy adult subjects carrying different SOD2 genotypes. The results showed differential antioxidant responses according to genotypes. Subjects AA showed a reduction in lipoperoxidation and DNA damage, but in these subjects, there was upregulation of thiols and GPX levels at enzymatic and mRNA expression levels. Taken together, our results corroborate the relevance of nutrigenetic effects of ingestion of some plants for modulation of the genetic SA-HP imbalance.
Keywords
nutrigenetic, brazil nut, oxidative stress, lipoperoxidation
