Abstract

Inflammatory response after resistance exercise occurs mainly in untrained subjects with exercises involving eccentric actions. Skeletal muscle is crucial in precise movement and your cells have a robust capacity of regenerated after injury, however, exercises involving eccentric actions, mainly in untrained subjects, induce muscular damage. This damage arises from muscle injury and may cause rupture and inflammation of muscle, connective or nervous tissues and produces a stereotyped inflammatory process. The inflammatory response is followed by muscle repair, regeneration, and growth, which involve activation, proliferation, and differentiation of satellite cells. Thus, this inflammatory response after muscle damage is fundamental to the adaptation of the skeletal muscle to exercise. Moreover, muscle damage decreases when a person performs the same exercise consistently and an attenuated inflammatory response to a repeated bout reflects in an adaptation to avoid the proliferation of the mechanical disruption of myofibrils. In addition, regular exercise is beneficial to upregulating defense mechanisms against oxidative stress, increased resistance against infection and a lower risk of appearance of disease.

Keywords

skeletal muscle, muscle inflammation, eccentric actions, oxidative stress, sarcomeric, contractile, cytoskeletal proteins, dystrophin, desmin, leucocyte accumulation, calcium homeostasis, cytoskeletal proteins, myostatin inhibitor, follistatin, inflammatory myopathies