Abstract

This study was carried out to evaluate gardicidal and amoebicidal activity of Anogeisus leicarpus variety supreme court leaves petroleum ether and methanol extracts in vitrotests were perform using four concentrations: (1000ppm, 500ppm 250ppm and 125ppm). The highest activity against Giardia lamblia, from petroleum ether leaves extract of Anogeisus leicarpus exhibit 77.02% mortality at concentration (1000ppm) after 72hours. On the other hand, the lowest antigiardial activity was recorded by methanolic extract 67.28% mortality with 1000ppm concentration in 27hours. The highest the activity against Entamoba histolytica, with respect to time, was obtained from methanolic extract which exhibited 70.06% mortality within 72h with a concentration of 1000 ppm. On the other hand, the lowest antiamobic activity was recorded by petroleum ether extract 61.35% mortality with 1000 ppm concentration within 72hours. This was compared with Metronidazole which gave 83.42% inhibition at concentration 312.5μg/ml at the same time. Our results revealed a pharmacological activity against G. lamblia and E. histolyticawe suggested that the extracts have the potential of being used in parasitic infection.

Keywords

Anogeissus leicarpus, gardicidal, amoebicidal, gentisic, protocatechuic, gallicacids, chebulagic acid, chebulinic acid, cathecin, quercetin, is quercetin, rutin, vitexin, kaempferol