Abstract

A new, simple, precise, accurate and selective method for ranitidine hydrochloride (RNH) quantification was developed based on the electrochemical oxidation of RNH on the pencil graphite electrode (PGE) modified with p-amino benzene sulfonic acid/cucurbit(6)uril (p-ABSA/CB (6)). During analysis, an electrochemical cell was employed with a conventional three-electrode system and (0.1molL-1) potassium chloride KCl solution as the supporting electrolyte. Under optimal experimental conditions, the peak current response increases linearly with a ranitidine concentration over the range of 2×10-4-1.7×10-2molL-1. The detection limit of the method was estimated to be 1.5746×10-4molL-1. To further validate its possible application, the proposed method was successfully used for the determination of RNH in pharmaceutical formulation. The scanning electron microscope was accomplished to investigate the structural behavior of the film that originated on the electrode surface.

Keywords

ranitidine hydrochloride (RNH), cucurbiturils, voltammetry, sulfonic acid, amino benzene, pencil graphite electrode, PGE, KCl solution, pharmaceutical formulation, H2-receptor, N-oxidation, S-oxidation, demethylation