Abstract

A series of 2H-oxeto[2,3-b]quinolines have been synthesized involving the simple steps of oxidation, reduction and cyclization of 2-chloro-3-formyl quinolines. All the synthesized compounds were evaluated for their antibacterial screening and anti oxidant studies. Most of the compounds showed moderate to good activity against almost all the tested pathogens. In particular, compound 1e showed good antibacterial and antioxidant activity.

Keywords

2-chloro-3-formyl quinolines, cyclization, oxetoquinolines, antibacterial, antioxidant studies, antimicrobial, antituberculosis, antimalarial, antiinflammatory, anticancer, antihypertensive, anti-HIV, synthetic protocol, 4N hydrochloric acid, sodiumborohydride reduction