Abstract

Objectives: This research aims at studying the impact of initial cervical dilation on the Atosiban efficacy in terms of prolongation of pregnancy.
Methodology:  A retrospective observational study of 84 pregnant women admitted to the hospital with a diagnosis of threatened preterm labor, and who received Atosiban as a tocolytic for prevention of preterm delivery (suppression of uterine contractions)
in the period 1st January 2015 till 31st December 2015 and their follow up till the timing of their delivery, data were collected using an online data collecting system through hospital online recording system. The inclusion criteria included pregnant
women  aged  between  18  years  and  35  years  old  in  whom  gestational  age  ranged between 24 weeks and 33 weeks and 6 days.
Results: Total of 84 cases were studied. Mean cervical dilatation at presentation was (1,9+0,25cm) with median of 2 cm. Two groups were made according to cervical dilation (<2 and ≥2cm). No significant deference between both groups for maternal
age  [p  value  0,59],  parity  [p  value  of  0.41],  Gestational  age  at  preterm  delivery diagnosis [p value 0.49], and Duration of the Atosiban [p value 0,54]. Atosiban Stop-Delivery interval was significantly deferred among the two groups [p value of 0,003]
as well as the gestational age at delivery [0,039]. Mean gestational age at delivery was 35 weeks (SD 1,3) and 33,2 weeks (SD 1,1) for cervical dilation <2 and ≥2 respectively [P=0,039]; 54% and 45% both groups respectively had Atosiban for 48
hours. 22,5% and 46% of both groups respectively delivered within 7 days of the diagnosis (p=0,034).
Conclusion: Our results showed that the Initial cervical dilatation has a significant impact  on  the  success  of  Atosiban’  hence  the  prolongation  of  pregnancy.  Such information is essential for decision-makers for a proactive approach.

Keywords

cervical dilation, agnosis, maintenance therapy, atosiban, age, parity, al distress, intrauterine infection, preterm delivery, gestational age