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Role of intravenous tranexamic acid on cesarean blood loss: a prospective randomized study


MOJ Women's Health
Manal A Farahat

Abstract

Background: Postpartum hemorrhage (PPH) is a major cause of maternal mortality globally. Tranexamic acid (an anti-fibrinolytic agent) is a novel approach to prevent this dreadful complication.
Aim of the work: The aim was to study the efficacy and safety of intravenous tranexamic acid in reducing blood loss during and after the lower segment cesarean section.
Patients and methods: In this prospective randomized clinical study, 200 mothers scheduled for elective CS were randomly selected and divided into two groups (study and control) of 100 each. The study group received 1 g IV tranexamic acid immediately before LSCS. And the control group received 30 ml of 5% glucose, all mothers received 10 units of oxytocin in 500 ml of normal saline.
Results: The mean intraoperative and postpartum blood loss was significantly lower in the study group than the control group.
Conclusion: Preoperative IV tranexamic acid significantly reduced blood loss during elective CS without any significant adverse effects.
 

Keywords

postpartum hemorrhage, tranexamic acid, cesarean section, pulse, respiratory, blood pressure, placebo groups, statistically, serum, comparison, post-operative, placebo

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