Perinatal complications of children born after assisted reproduction treatments, is there a difference with those born by spontaneous pregnancy? results in 2 centers
- International Journal of Pregnancy & Child Birth
Hector Salvador Godoy Morales,1 German Gabriel Palacios Lopez,2 Griselda Claribel Reyes Torres,3 Pablo Joaquin Cervantes Mondragon,3 Daniel Vieyra Cortés,3 Hilda Sanchez Hernández,3 Miguel Loyo Guiot3
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Background: The assisted reproduction treatments (ART) have been increasing and it has been controversial if patients born after these have or not major adverse perinatal events and repercussions on their health.
Objective: To compare if there are more perinatal complications in a group of live births after ART in a private hospital against a group of spontaneous live births in a public institution.
Methodology: Observational, comparative, retrospective and cross-sectional study of patients from 2008 to 2018 at the Hospital Angeles, Mexico City (cases) and the Military Hospital of Specialties of Women from 2016 to 2017 (controls). In the case group, we included patients treated with ART, without age limit, either by their own embryos, donated embryos or by oocyte donation; we evaluated the presence or absence of obstetric complications (preeclampsia, gestational diabetes, threatened preterm delivery), and complications at birth (obstetric hemorrhage, early neonatal death, malformations). In the control group, we evaluated the same factors. The statistical analysis was by descriptive statistics and by elaborating 2X2 tables of contingency, to obtain odds ratios and relative risks.
Results: 124 cases, for the control group 290 patients. Regarding pregnancies in the case group, 62% were obtained with their own oocytes. The day of transfer with most pregnancies was day 3 (47.5%). The average number of cycles to achieve pregnancy was 2.2, the frequency of multiple pregnancies by ART was 23.4%. When comparing groups, evaluating risks between them to present or not obstetric complications, we analyzed the most frequent ones; the group of cases was a factor that was associated with having no complications (OR 0.328 CI 0.188-.573), but with a higher risk of preterm labor threat (OR 3.06 IC 1.725-5.456). Regarding other complications, no significant differences were found.
Conclusions: With the present study, we add evidence that there are no major obstetric and perinatal risks and complications after births of children conceived by ART.
assisted reproduction treatments, spontaneous newborns, obstetric, perinatal, complications