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Thermostability of attenuated measles virus vaccine in Pakistan

International Journal of Complementary & Alternative Medicine
Syeda Shazia Adeel,1 Muhammad Babar Taj,2 Amina Najam,3 Mohammad Asghar,4 Rafiq Ahmed Channa,4 Tanvir Ibrahim,4 Ghazala Parveen4


Attenuated measles virus (MV) is an attractive candidate to prevent infectious disease like measles thus making it a safe and effective vaccine available against this can be a fatal disease. In countries like Pakistan having hot and humid climate stability of vaccine, the titre is the important and foremost factor for successful immunization session. Prevalence of measles virus can increase due to the ineffective or poor-quality vaccine. To ensure the quality and efficacy of the vaccine WHO has taken numerous measures and made guidelines for regulatory authorities. The current study highlights the consistency of measles vaccine at raised temperatures. In this study, 30 batches were tested. The stability studies were carried out on finished products stored at 2-8°C and raised the temperature of 37°C for seven days in accordance with ICH Guidelines of stability testing of Biological products. This study provides an evaluation of real-time stability shelf life and thermostability studies. The verdicts specify long-term thermostability and verify that this vaccine can remain effectual under the setting of routine use when recommended procedures for storage and handling are tracked in factual essence.


WHO, world health organization, MV, measles virus, MMR, mumps & rubella, MR, measles-rubella, CCID50, cell culture infected dose, CPE, cytopathic effect, WHO, immunization, diarrhoea, pneumonia, vaccination