Abstract

Objectives: is to evaluate Insulin, Metformin and Glibenclamide in control of gestational diabetes mellitus.

Background: Gestational   diabetes   mellitus   [GDM]   is   a   common   complication   of   pregnancy. Blood glucose control improves perinatal outcomes. Medical nutrition therapy is the milestone management.

Methods: In  our  prospective  observational  cohort  comparative  study,  360  patients  with  GDM  and  did  not  controlled  by  diet  alone  who  were  attending  at  clinics  at  Obstetrics  Department in Menoufia University Hospitals from November 2016 to November 2017.They  were  separated  into  three  groups,  group  1  contain  120  patient  received  insulin,  group  2  contain  120  patient  received  metformin,  group  3  contain  120  patient  received  glibenclamide. We compared the results of maternal glucose level, maternal complications and neonatal outcome in each group.

Results: We found no significant change in blood sugar control, maternal complications or neonatal results with the use of insulin, metformin or glibenclamide.

Conclusion: Good  glycaemic  results  in  GDM  can  occur  by  giving  glibenclamide  or  metformin with similar risk of maternal complications and fetal outcome to use of insulin. So oral hypoglycemic drugs can replace insulin in cases with GDM in pregnant Egyptian womens.

Keywords

insulin, metformin, glibenclamide, glucose tolerance test, gestational diabetes mellitus, blood sugar control, maternal complications, neonatal, contraindication, renal impairment, hypertension, pre-eclampsia, glycemic control, medical complications, termination