Can Oral hypoglycemic drugs replace Insulin for management of patients with gestational diabetes mellitus in pregnant Egyptian women’s: Observational study?
- MOJ Women's Health
Ibrahim Saif Elnasr, Hesham Ammar
Objectives: is to evaluate Insulin, Metformin and Glibenclamide in control of gestational diabetes mellitus.
Background: Gestational diabetes mellitus [GDM] is a common complication of pregnancy. Blood glucose control improves perinatal outcomes. Medical nutrition therapy is the milestone management.
Methods: In our prospective observational cohort comparative study, 360 patients with GDM and did not controlled by diet alone who were attending at clinics at Obstetrics Department in Menoufia University Hospitals from November 2016 to November 2017.They were separated into three groups, group 1 contain 120 patient received insulin, group 2 contain 120 patient received metformin, group 3 contain 120 patient received glibenclamide. We compared the results of maternal glucose level, maternal complications and neonatal outcome in each group.
Results: We found no significant change in blood sugar control, maternal complications or neonatal results with the use of insulin, metformin or glibenclamide.
Conclusion: Good glycaemic results in GDM can occur by giving glibenclamide or metformin with similar risk of maternal complications and fetal outcome to use of insulin. So oral hypoglycemic drugs can replace insulin in cases with GDM in pregnant Egyptian womens.
insulin, metformin, glibenclamide, glucose tolerance test, gestational diabetes mellitus, blood sugar control, maternal complications, neonatal, contraindication, renal impairment, hypertension, pre-eclampsia, glycemic control, medical complications, termination