Implementing pharmacogenetics in private clinical settings
- International Journal of Family & Community Medicine
Mark Stengler NMD
Pharmacogenetics is a rapidly advancing field of genetic medicine that offers promise for improved patient outcomes. Prescription drugs dominate the medical system, which makes it imperative to utilize technology which identifies gene-drug compatibility. Clinicians in a private clinical setting must understand the definitions and science behind pharmacogenetics (PGx). There are at least five good reasons for clinicians to implement PGx into their practice. There is emerging research demonstrating that PGx can decrease hospital admissions as well as adverse drug events in large specialties such as cardiology, oncology, and psychiatry. In some situations PGx has been demonstrated to be cost-effective. Drugs that have compelling gene-drug research included in this review include warfarin, clopidogrel, cholesterol-lowering statins, abacavir, antidepressants, and irinotecan. There are also limitations to evidence-based gene-drug interactions that clinicians should be familiar with. Lastly, there are several considerations that clinicians should be aware of in regards to legal and ethical concerns.
pharmacogenetics, pharmacogenomics, drug-gene, clinical genetics, drug response, PGx, adverse drug event