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Parinaud syndrome: dusting off a localizing entity

Journal of Neurology & Stroke
Vanessa Salej, Felipe Botero-Rodríguez 

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Parinaud syndrome is a set of signs and symptoms that localize a lesion to the dorsal midbrain. It was first described by Henri Parinaud during the late the 1800 s, consisting initially of an upgaze palsy in combination with a convergence paralysis. Nowadays, it comprehends a tetrad made up of: upgaze palsy, convergence retraction nystagmus, pupillary light-near dissociation, and lid retraction (Collier´s sign). The purpose of this review is to retrieve this historical syndrome by giving account of the recent data published on its etiology, clinical presentation and treatment strategies, as well as by giving a brief notice about Henri Parinaud, by whom the syndrome bears its name. Recently published data has given some new insight on the etiology in adults. Similarly, reports on the frequency of each clinical sign have allowed us to establish their localizing value. Treatment strategies depend largely on the cause; however, interventions for the management of symptoms and secuelae have also been described.


parinaud syndrome, dorsal midbrain syndrome, ocular motility disorders, ophthalmologist, pathophysiology, neurological, etiology, midbrain, superior coliculli, medial longitudinal fasciculus, insterstitial nucleus of Cajal