Abstract

Effluent from basic drug industries may have unknown toxicity, teratogenicity and carcinogenicity profile associated with lack of monitoring and control measures impose a significant hazard risk on the public health and biological environment. Therefore study of toxicity of the treated effluent from effluent treatment plant of basic drug industries of Mandideep industrial area near Bhopal city of Madhya Pradesh, that large number of suppliers of bulk drugs to the international market as well as to local market. Total two basic drug industries were selected in Madideep industrial area for bioassay test by Poecilia libestes reticulate (Guppy fish). Monitoring of basic drug industrial effluents was performed as per guidelines of Central Pollution Control Board and bioassay test was performed as per BIS: 6582 (1971) method. This study concluded by graphical values of 90 % survival of tested fishes at 50 % dilution in 96hrs, that represented as lethal concentration50 (LC₅₀). The observation reveals that 6 % LC₅₀of effluent from ETP II Lupin Ltd during II quarter, 85% LC₅₀of effluent from ETP I Lupin Ltd during III quarter, 11.23% LC₅₀of effluent from ETP II Lupin Ltd during III quarter, 5% oLC₅₀of raw effluent from Vista Organics (P) Ltd during III quarter and 42.5% LC₅₀of mixed effluent from ETP I & ETP II Lupin Ltd during IV quarter were found acute toxic during this study. Treated effluent from both industries was found Free from acute lethal toxicity w.r.t. Bio Assay Test.

Keywords

basic drug industry, effluent treatment plant, treated effluent, bioassay test, LC50