Abstract

The  goal  was  to  Develop  a  systematic  review  of  randomized  clinical  trials,  Masked  and  controlled with or standard placebo drug on the safety and efficacy of Passiflora incarnata (passion  fruit),  Matricaria recutita (chamomile)  and  Melissa officinalis (lemon  balm)  to  Generalized Anxiety Disorder treatment. The articles were fetched in PubMed, Scielo and Google Scholar date basis. Selected articles met the eligibility criteria That Were Evaluated and detailed in tables containing the authors, location, year, inclusion and exclusion criteria, results, verified by validated efficacy criteria for diagnosis and prognosis of GAD and the existence of interest conflicts. There were selected only 7 of the 1471 articles found. In studies with Passiflora incarnata, there was a significance of the Passiflora Compared to placebo effect and the standard drug, getting Decreased anxiety without inducing sedation. The study was conducted with Matricaria recutita, suggesting it may have mild anxiolytic effects in anxiety cases. Two studies were carried out with Melissa officinalis, one with interest conflicts, and another suggesting que its use may be adequate and secure. The conclusion  is  que  was  used  to  low  sample  size  in  the  seven  studies  included,  showing  inconclusive results, the presence of conflicts of interest as well as several types of biases. Thus, the are scientific evidences insufficient to prove the efficacy and prescription guided by scientific evidence of phytotherapy these medicines for Generalized Anxiety Disorder.

Keywords

anxiety, phytotherapic and clinical trial, dry mouth, sweating, chills, tremor, vomiting, palpitations, and abdominal pain, pathological anxiety