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Development a quantitative method for the determination of misoprostol acid in human serum


Abstract

There has been conducted an experimental study and longitudinal design with which method highly sensitive and specific has been developed, using the equipment ultraperformance liquid chromatograph with a detector mass - mass (UPLC - MS - MS) for the qualitative and quantitative determination of ester misoprostol through its metabolite misoprostol acid in serum samples. A peak was obtained at 2.2 min of chromatographic running and the results are between 3.1 and 18,4ppb.

Keywords

acid misoprostol, serum samples, liquid chromatography, metabolite, solid phase extraction

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