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Physical activity and prostate cancer: a systematic review


Urology & Nephrology Open Access Journal
Abdalla Ali  Deb,1 Okechukwu Emmanuel,Shady Emara,3  Sami A Abbas4

Abstract

Numerous studies confirmed that planned exercise therapy is a possible adjunct strategy connected with significant improvements in symptom-related results including exercise tolerance as well as several cancer patients-reported progress such as improvement in quality of  life,  and  physical  functioning  during  conventional  adjuvant  therapy.  The  aim  of  this  review was to evaluate the association between physical activity and prostate cancer. Apart from lung cancer, prostate cancer is highly prevalent among men. We searched for original articles, systematic reviews, and meta-analyses that reported on exercise-mediated changes in the prostatic tumour risk and progression from 1980 to 2018. The following electronic databases  was  used:  PubMed,  Science  Direct,  Medline,  Sports  Discus,  Web  of  Science,  Google Scholar and Cochrane database. 85 studies written in English were included in this review. Patient’s cardio-metabolic profile, type of exercise, specific workloads, frequency, duration,  intensity  and  safety  precautions  are  factors  to  consider  when  scheduling  an  exercise program. Regular participation in physical activity is important in the prevention of prostate cancer and it is associated with positive treatment outcomes in patients undergoing Androgen  deprivation  therapy.  Physical  Activity  may  affect  prostate  cancer  progression  by reducing insulin resistance, decreasing bioavailable Insulin-like growth factor 1 (IGFI), increasing adiponectin levels and circulating levels of insulin. Interleukin 6 (IL-6) promotes cell proliferation and inhibits apoptosis of prostate cancer cells in vitro. Physical activity is  associated  with  lower  circulating  IL-6. Based  on  the  information  examined  in  this study, physical activity may be an effective nonpharmacological means in the treatment of prostate cancer.

Keywords

physical activity, exercise, prostate tumor, cancer prevention

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