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Comparative study of in vitro antioxidant and anti-inflammatory potentials of two malvaceae used in folk medicine in Burkina Faso


International Journal of Complementary & Alternative Medicine
Emmanuel AM Thiombiano,1 Mindiédiba Jean Bangou,1,2 Tangbadioa Hervé Coulidiati,1,3 Pierre Alexandre Eric Djifaby Sombié,1,4 Martin Kiendrébéogo1

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Abstract

The purpose of this study was to evaluate and compare the in vitro antioxidant and anti-inflammatory potentials of Wissadula amplissima (L.) and Abutilon grandifolium (Willd.) Sweet, two malvaceae used in the traditional medicine in Burkina Faso. Aqueous, ethanolic and hydroacetonic extracts of these species were used for different assays. Total phenolic and total flavonoid contents were determined using spectrophotometric methods. Antioxidant capacities of the extracts were screened using four methods: DPPH free radical scavenging, ferric reducing antioxidant power (FRAP), total antioxidant capacity (TAOC) and anti-lipid peroxidation assay. The different extracts were also assayed on xanthine oxidase, lipoxygenase and cyclooxygenases 1 and 2 to establish in vitro, their anti-inflammatory potentials. Results obtained revealed that the two Malvaceae species were rich in phenolic and flavonoid compounds. These compounds may have antioxidant and anti-inflammatory properties, as in this study we have highlighted the antioxidant capacities and the anti-inflammatory potential of the extracts from the two species. W. amplissima and A. grandifolium can be important sources of bioactive molecules with antioxidant and anti-inflammatory properties.

Keywords

FRAP, ferric reducing antioxidant power, DPPH, TAOC, total antioxidant capacity, GAE, gallic acid equivalent, QE, quercetin equivalent, LPI, lipid peroxidation inhibition, AAE, ascorbic acid equivalent, ROS, reactive oxygen species, NOS nitrogen oxygen species, XO, xanthine oxidase, LOX, lipoxygenase, COX 1, cyclooxygenase 1, COX 2, cyclooxygenase 2, antioxidant, anti-inflammatory, abutilon grandifolium, wissadula amplissima

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