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Hematological characterization of beta thalassemia in Sudanese patients


Hematology & Transfusion International Journal
Rabab Hassan Elshaikh,1 Sanaa Elfatih Hussein2

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Abstract

Thalassemia is common inherited disorder among humans, and they represent a major public health problem in many areas of the world. The study aimed to characterize the hematological features of beta thalassemia in Sudanese patients. Blood samples from 61 beta thalassemic patients were collected after written consent form obtained from all participants. The frequency of Adults (>18 years) were 45 (73.8%), and Children’s (<18 years) were 16 (26.2%). The frequency of male was 27 (44.3%) and 34 were females (55.7%). Hemoglobin estimation and red cell indices were carried out using the automatic blood cell counter Sysmex KX21N. Hemoglobin concentration (Hb) with the mean value of 9.6 g/dL, with minimum value of 6.1g/dL and maximum of 11.9g/dL, while RBCs was increased in all patients, mean value 5.2c/L, Mean corpuscular volume (MCV) mean was 58.9 fL, hematocrit was 30.4, mean corpuscular hemoglobin (MCH) 18.8 pg, mean corpuscular hemoglobin concentration (MCHC) was 31.7pg and RDW was 18.8%. Hb pattern shows increased HbA2 and HbF the mean of HbA is 78.3%, HbF is 2.3% and HbA2 is 6.5% with the min value of 3.6% and max of 12.2%. While the mean of serum iron was 82.75ug/dL, 7 patients showed low level, 19 high level and 35 was normal level. Comparison of hematological analysis (HbA2) in thalassemic patients coexisted with Iron deficiency and without result was insignificant difference (P = 0.645).

Keywords

thalassemia, RBCs indices, Hb electrophoresis, CBC, iron, Sudan

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