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Effects of dexamethasone, cyclosporine and betamethasone on inflammatory cell recruitment in mice infected with Strongyloides venezuelensis


Journal of Lung, Pulmonary & Respiratory Research
Eleuza R Machado,1,2 Marlene T Ueta,3 Rosângela Maria Rodrigues,4 Simone G. Ramos,5 Viginia Vilhena,6 Anna Maly de Leão e Neves Eduardo,2 Leandro Junio Barreto dos Reis,2 Raphael da Silva Affonso,2 Lúcia Helena Faccioli1

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Abstract

The objective of this study was verified effect of immunosuppressant activities of Dexametasone (Dexa), Cyclosporine (CsA) and Betamethasone (Beta) in the synhteses of inflammatory cell and dissemination of Strongyloides venezuelensis. S. venezuelensis-infected mice increased total leucocytes (TL), eosinophil (EO), mononuclear cells (MC), and neutrophil (NE) numbers in the blood. The infection induced recruitment of TL, EO and MC to peritoneal cavity (PCF) and space bronchoalveolar (BALF), exception for NE. Dexa, CsA and Beta treatments inhibited TL, EO and MC production. However, Dexa treatment was associated with NE accumulation in the blood. Dexa and Beta tratments reductions migration of inflammatory cells from the blood to PCF and BALF. Infected mice and treated with Dexa and Beta worm parasites, eggs/g/feces and larvae recovered were higher than CsA. The results showed that glucocorticoid treatment may induce strongyloidiasis dissemination while CsA induced mice protection against S. venezuelensis infection.

Keywords

strongyloides venezuelensis, dexamethasone, cyclosporine, betamethasone, immunossupression, hyperinfection

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