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Total synthesis of the civet constituent (-)-2-((2R, 6R)-6-methyltetrahydro-2H-pyran-2-yl) acetic acid

MOJ Bioorganic & Organic Chemistry
Fátima Garrido,1,2 Hugo Santalla,1,2 Generosa Gómez,1,2 Yagamare Fall1,2

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We describe the total synthesis of a glandular secretion of the Civet Cat, using tri-O-acetyl-D-glucan, a cheap and commercially available chiral building block.


Tetrahydropyran, Civet cat compound, Natural product, Glandular secretion, Chiral reagent, MOM protection, Wolf-Kushner reaction, Alcohol