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Evaluation of antioxidant properties of angiotensinconverting enzyme inhibitors-interactions with free radicals model examined by EPR spectroscopy


Pharmacy & Pharmacology International Journal
Anna Juszczak,1 Pawel Ramos,2 Wojciech Szczolko,3 Barbara Pilawa,2 Beata Stanisz1

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Abstract

Angiotensin-converting enzyme inhibitors (ACE-I) are the most popular drugs used in the modulation of renin-angiotensin-aldosterone system (RAS) activity. ACE-I show variable and complex biological activities, which determine the diversity of possible clinical use. Since it is known, that oxidative stress is the precursor of many pathologies and disorders, the antioxidant activity of drugs has emerged as a pharmacologically significant factor. There are a lot of clinical reports that intake of ACE-I improve conditions of patients with neurodegenerative disorders and may slow inflammatory processes. The aim of the study was a comparative analysis of antioxidant properties of the cilazapril, ramipril, imidapril, lisinopril, perindopril, and quinapril. EPR spectroscopy was used to examine chosen ACE-I interactions with the free radical model. Amplitude (A) of EPR lines of DPPH (reference), and DPPH interacting with the tested ACE-I were compared. Kinetics of interaction for tested ACE-I with DPPH, up to 30 minutes, was obtained. The most substantial interaction with DPPH was observed for cilazapril and the lowest for lisinopril. Studies have shown usefulness EPR spectroscopy for investigation interactions of ACE-I with the free radical model.

Keywords

angiotensin-converting enzyme inhibitors (ACE-I), antioxidant, free radicals, EPR spectrometry, UV-Vis spectrophotometry

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