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Synthesis, characterization, anticancer activity and biological activities of vanadium complexes of 2-mercapto-5-methyl-benzimidazole as sulphur donor ligand

Journal of Analytical & Pharmaceutical Research
Mudassir Jabeen,1 Saqib Ali,2 Saira Shahzadi,2 Liwu Fu,3 Muhammad Shahid,4 Matloob Ahmad1


Vanadium complexes have been synthesized by the reaction of 2-mercapto-5-methyl-benzimidazole with carbon disulphide and then with different vanadium salts in different M/L ratio. The synthesized vanadium complexes have been characterized by elemental microanalysis (CHN), FT-IR spectroscopy and NMR (1H, 13C) spectroscopy. Elemental analysis data shows good agreement between found and calculated values. FT-IR spectroscopic data suggests the bidentate nature of the ligand. The results of multinuclear NMR revealed that coordination occurs through NCS2 moiety. Antibacterial activity data showed that ligand and complexes showed moderate antibacterial and anti-biofilm activity. The cytotoxicity studies showed that vanadium complex (3)is less cytotoxic (2.27%) and complex (1) has maximum cytotoxicity (11.04%). In vitrooxidative DNA damage protection assay showed that synthesized vanadium complexes exhibited plasmid DNA protection by scavenging the oxidation products. Results of in vitro anticancer activity showed that oxoperoxo vanadium complex (2) exhibited significant anticancer activity (IC502.55μM) against H460 MX2 cell line.


vanadium complexes, synthesis, characterization, anticancer activity, biological activities