Abstract

The outbreak of Coronavirus which initiallybegan in China,in the year 2003has caused several major public health concerns which resulted in epidemics globally, such as, severe acute respiratory syndrome (SARS)&Middle East respiratory syndrome (MERS). Most recently,i.e. in late December 2019, authorities identified an ongoing outbreak of the novel coronavirus (2019-nCoV), recently named as COVID-19caused by SARSCoV-2which originated in Wuhan, Hubei Province, China. It probably marked the third highly pathogenic coronavirusesspreading globally,causingsevere respiratory ailments and pneumonia-like infections in the humans.2019-nCoV exhibits similar genome organization, genetic, and epidemiological features to the other known CoVs. The COVID 19 virus has been declared as an inter-human transmissible virus which readily spreads mainly through the respiratory droplets produced when a person infected with coronaviruscoughs, sneezes or talks.In a short stretch of time, this epidemic had spread to 210Countries and Territories with 16,20,500confirmed cases, including 97,400 confirmed deaths. Currently, the Mortality rate of COVID 19 is 2-5% only compared to SARS and MERS Coronaviruses. The older people are at a higher risk of COVID-19 infection due to their reduced immunity and body reserves, as well as multiple associated comorbidities like hypertension,diabetes, cancer and chronic obstructive pulmonary disorders.Till date, there is no effective antiviral drug or licensed vaccine available to treat this infectious disease. As the infection is a recentlyadvancing pathogen, severalqueries remain unanswered concerning the virus’s reservoirs, pathogenesis, transmissibility, and much more is unknown. Herein, this article comprehensively reviews the currently available information on the virology, epidemiology, clinical presentation, diagnosis, and treatment of COVID-19

Keywords

COVID 19, structural proteins, ACE 2, replication process, transmission, clinical features, diagnosis, antiviral drugs, vaccines