Abstract

The metabolic syndrome (MS) is a complex multi-factorial disease associated with obesity (OB), type 1 diabetes mellitus (DM1), type 2 diabetes mellitus (DM2) and high blood pressure (HBP). This study included 404 subjects selected at Giurgiu Country Hospital, on the basis of clinical evaluation and of biochemical and hematological laboratory investigations, and the sequencing of 28 genes of interest: INS, IGF2, TGF-beta, HSPG Bam H1, ACE, UCP2, FABP2, PLIN1, PON1, FTO, ADRB3, BHMT2, MTHFR, IRS1, TRPM6, MT1A, APOA5, PEMT, ABCB4, CHDH, FADS2, PCYT1A, PCYT1B, PNPLA3, SCD, SCL44A1, STAT3 in identifying the high risk of developing metabolic syndrome. The findings were statistically processed by the MDR and Jalview programs.

Keywords

genes, MDR, Jalview, metabolic syndrome