Abstract

Urinary tract infection (UTI) is the commonest bacterial infectious disease in community practice with a high rate of morbidity and financial cost. It has been estimated that 150 million  people  were  infected  with  UTI  per  annum  worldwide  which  costing  global  economy more than 6 billion US dollar. In humans, urinary tract is the second commonest site  after  the  respiratory  tract,  for  bacterial  infection.  Two  hundreds  forty  seven  diabetic  patients  were  investigated  for  UTI  using  5  to  10ml  midstream  urine  sample.  A  loop  full urine sample was inoculated on cysteine lactose electrolyte deficient (CLED) agar, MacConkey agar and Blood agar plates. Antimicrobial susceptibility test was done using Clinical  and  Laboratory  Standards  Institute  (CLSI)  for  all  patients. Age,  sex,  resident, marital status and other factors were used as exposure factor of the cross sectional study. The  aim  of  this  study  was  to  assess  etiology,  risk  factors  and  drug  sensitivity  pattern  of  uropathogenic bacteria isolated from diabetic patients. The overall prevalence of significant bacteriuria was 26(10.5%). Significant bacteriuria was significantly associated with age and  body  mass  index.  The  predominant  bacteria  isolate  was  E.  coli  12(46.2%)  followed  by Coagulase negative staphylococcus 7(26.9%).Gram negative bacteria showed high rate of sensitivity (94.1%) to Nitrofurantoin and Norfloxacine. Gram positive bacteria showed 100% sensitive for Amoxacillin-Clavunic acid. Multidrug resistance to two or more drug was observed in 19(73.1%) of bacteria isolates. The overall prevalence of significant UTI in diabetic patients was 10.5%. The most frequently observed organisms were E. coli, CONs, K. pneumoniae, K. oxytoca and S. aureus. Sex, age, BMI, occupational status such as house wife was statistically significant. Gram negative bacteria isolates were the most common antibiotic resistant bacteria isolates from UTI patients.

Keywords

diabetes, UTI, uropathogens, antimicrobial susceptibility