Abstract

Pure white cell aplasia (PWCA) is a rare acquired cause of agranulocytosis characterized by absence of all myeloid lineages in bone marrow with intact erythropoiesis and megakaryopoiesis. Reported cases were associated with autoimmune conditions, thymomas, chronic lymphocytic leukemia, infections, and as an adverse drug reaction. Presentation ranges from asymptomatic severe neutropenia to fatal sepsis. Several medications were tried along with treatment of the underlying cause if identified. Steroids, immunoglobulin, azathioprine, cyclosporine, rutiximab, GCSF and bone marrow transplant were all tried with variable response. Here we report a case of PWCA in middle age male, who responded to cyclosporine.

Keywords

cell aplasia, cyclosporine, rutiximab, bone marrow transplant