Abstract

The amyloid Aβ-42, a peptide involved, following a conformational change in β sheets in the pathology of the main neurodegenerative disorder of Alzheimer’s disease, is targeted in our study, the latter of which reports the synthesis of two Inhibitors linked to a specific recognition sequence synthesized during this work (Tryp-Val-Val-COOH), one linked to an aziridine and the other to a methylated β-CD in order to be able to stop the aggregation of the peptide involved.

Keywords

Alzheimer, peptidomimetic, cyclodextrin, fibrillogenesis