Background: Buschke-Löwenstein tumor is a presentation of condyloma acuminata; causedby human papillomavirus infection presenting as an exophytic, polypoid, cauliflower-likelesion; characterized by slow growth, local infiltration, contiguous tissue destruction; with atendency to recurrence and produce fistulas or abscesses around the affected area. The mostfrequent location is the vulva, scrotum, penis, perineum and perianal region; Transmitted bysexual contact and more common in men, it is controversial whether it should be consideredpremalignant or a verrucous carcinoma; It does not present cellular atypia and a third canbecome malignant; recurrences are frequent. The risk factors are HPV, continuous irritationand poor hygiene of the genital area, phimosis, immunosuppression, smoking and drugaddiction.

Objective: review literature and case description.

Case presentation: 45-year-old male with condylomatous lesion on the genitals of 4months’ duration, on the foreskin and ligament of the glans penis, and other minor lesionson the shaft of the penis; morbid obesity, uncontrolled type 2 diabetes mellitus. He isscheduled for circumcision and removal of the satellite lesions.

Conclusion: Giant Buschke-Löwenstein condyloma is considered a low-grade squamouscell carcinoma, locally invasive, with aggressive behavior; Surgical treatment is the option.