Superficial radiotherapy and volumetric modulated Arc therapy for skin cancers within hamartomatous skin in patient with PTEN mutation: A case report
- International Journal of Radiology & Radiation Therapy
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Nicole El-Turk, Nicola Holt, Tina Gorjiara, Gavin Gottschalk, Laurence Krieger, Lucinda J. Berglund, Gerald B. Fogarty
Abstract
Phosphatase and tensin homolog (PTEN) gene acts as a tumour suppressor gene. Mutations of this gene are a step in the development of many cancers. Sufferers can have large fields of symptomatic hamartomatous skin change especially in sun exposed areas. RT has been reported to cause increased acute toxicity in this cohort.
Keywords
PTEN, PTEN hamartoma tumour syndrome, hamartomatous skin change, Australia, skin cancer, basal cell carcinoma, superficial radiotherapy, volumetric modulated arc therapy, toxicity
