Abstract

In this study, we reported our previous observations and perceptions regarding the involvement of neurological components in the malignant tissues. We used to examine different tissues with malignancy, and we observed increased involvement of neurological components as peripheral nerves. At the beginning, no plausible explanation to such phenomenon. Later, we showed in diabetic rat model that white matter was involved in diabetic progression through the up-regulation of inducible nitric oxide synthase (iNOS) and the down-regulation of heat shock protein70 (HSP70). We extended our investigations in other organs in the same model including kidney, liver, testes, and prostate. We found the same phenomenon of the expression of iNOS and HSP70 in the tissues of these organs. We also observed that there was a deterioration of tissue architecture due to diabetic effects. We think that this deterioration may result from the neurological involvement in these tissues. However, because diabetes may result in initiation of some tumors such as endometrium cancer, deterioration of tissue architecture and neurological involvement are becoming more importantly. This study aimed to introduce our hypothesis in this issue “Architecture deterioration as a new medical hypothesis explaining cancer progression”. We also reviewed the relevant literature.

Keywords

tissue, architecture, deterioration, diabetes, malignancy, cancer progression