Abstract

Autoinflammatory diseases encompass a group of rare pathologies characterized by acute and recurrent inflammatory episodes. Their clinical manifestations are very diverse and can affect practically any organ. The confirmatory diagnosis is based on genetic study but must be performed and interpreted correctly. Treatment with biologic drugs that block proinflammatory cytokines has been shown to be effective in a large proportion of patients.

Keywords

Autoinflammatory diseases, Interleukin-1beta, macrophage activation syndrome, RIPK1, CRIA