A case of a schizophrenic patient with unusual pharmacogenetics profile
- Pharmacy & Pharmacology International Journal
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Igor I Miroshnichenko,1 Natalia V Baymeeva,1 Svetlana A Ivanova,2 IV Pozhidaev,2 Anastasia A Beburishvili,1 Vasiliy G Kaleda1
Mental Health Research Center, Russian Federation, Russia
Abstract
There are plenty of evidencessupporting the contribution of genetic variability to the mechanisms that responsible for both therapeutic and adverse effects of antipsychotic medications. We report a case that is an example of using cytochrome P450 pharmacogenetics and therapeutic drug monitoring in an attempt to guide schizophrenia treatment. This example illustrates the potential of applying the principles of predictive, preventive, and personalized medicine to the therapy of psychotic disorders.
Keywords
Schizophrenia, Pharmacogenetics, Therapeutic drug monitoring, Antipsychotic Drugs, Genetic variability, P450, +MRM
