Histopathological pattern of colorectal cancer in relation to age and gender in northern saudi arabia
- Journal of Cancer Prevention & Current Research
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Hussain Gadelkarim Ahmed,3
Gamal
Mohammed Alawad,1
Saleh Hadi Alharbi,2
Fayez Saud Alreshidi,1
Abdullah Dakheel
Alotaibi,1
Ahamad Alamin Alshaikh1
College of Medicine, University of Hail, Kingdom of Saudi Arabia KSA - Gamal Mohammed Alawad, Department of Clinical Laboratory, College of Applied Medical Science, University of Hail, KSA
- Saleh Hadi Alharbi, College of Medicine, University of Hail, Kingdom of Saudi Arabia KSA
- Fayez Saud Alreshidi, College of Medicine, University of Hail, Kingdom of Saudi Arabia KSA
- Abdullah Dakheel Alotaibi, College of Medicine, University of Hail, Kingdom of Saudi Arabia KSA
- Ahamad Alamin Alshaikh, Department of Surgery, University of Aljazera, Sudan
Abstract
Background: Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. There are different histopathological variants of CRC that differ in behavior and means of management. Therefore, the aim of this study was to determine the different types CRC in relation to age and gender in Northern KSA.
Methodology: A retrospective cohort study was carried out over a five year period in different referral hospitals. In this study 120 files were retrieved from departments of Surgery from different hospitals in Northern KSA.
Results: Most patients presented with colonic site tumors constituting 67/120(55.8%), followed by Recto-sigmoid, and Rectum representing 31/120(25.8%) and 13/120(10.8%) respectively. Adenocarcinoma (AD) was diagnosed in 105/120(87.5%).The great majority of patients were categorized with moderately differentiated carcinoma representing 76/120(63.3%), followed by well differentiated and poorly differentiated carcinomas constituting 35/120(29.2%) and 9/120(7.5%), respectively.
Conclusion: Saudi patients with CRC were more expected to present with more advanced stages of the disease and at younger ages compared to Western populations, which presents more frequently in an extra advanced stage and poorly differentiated type than in older patients.
Keywords
Colorectal cancer, Saudi Arabia, Adenocarcinoma, Colon, SCNA, CRC, Microsatellite instability, Chromosomal instability, Statistical Package for Social Sciences, Primary tumor
