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Targeting dysfunctional mitochondrial metabolism of hepatocytes caused by hepatitis B virus (HBV) in the treatment of the chronic HBV infection- a narrative review


Journal of Human Virology & Retrovirology
Dr. Kulvinder Kochar Kaur M.D,1 Dr. Gautam Nand Allahbadia M.D, D.N.B,1,2 Dr. Mandeep Singh M.D. DM3

Abstract

Mitochondria possess a significant part in generation of adenosine triphosphate (ATP), Reactive oxygen species (ROS), in addition to the controlling of the innate immune reactions along with apoptosis. Numerous viruses interfere with the mitochondrial actions for facilitating their replication along with result in cell injury. Hepatitis B virus(HBV) portrays a hepatotropic virus which possesses the capacity of resulting in robust liver diseases inclusive of cirrhosis in addition to Hepatocellular carcinoma(HCC).This virus further possesses the capacity of changing the mitochondrial working in addition to metabolism for facilitating its replication along with their continuation. Having earlier reviewed the part of generation besides the epigenetic controlling of the ccc DNA micro chromosome, the manner host as well as viral factors impact transcription besides if utilization of epigenome editing could be done for silencing HBV ccc DNA forever and why persistence of HBV takes place besides mitochondrial metabolism, mitophagy in ageing and role in fatty acid metabolism here we have concentrated on Hepatitis B virus(HBV) along with described the recent advancements in our acquisition of knowledge regarding the association amongst HBV in addition to mitochondrial metabolism. Here we conducted a narrative review utilizing search engine pubmed, Google scholar; web of science; embase; Cochrane review library utilizing the MeSH terms like Hepatitis B virus; mitochondrial metabolism; mitophagy; CD8+T cells; oxidative phosphorylation (OXPHOS);viral replication; viral persistence. We have detailed the recent advancements in the crosstalk HBV as well as mitochondrial metabolism in addition to its actions on HBV replication in addition to persistence as well as how utilization of this knowledge can help in treatment of chronic Hepatitis B (CHB) infection.

Keywords

hepatitis b virus (HBV) infection, mitochondrial metabolism, viral replication, persistence, oxidative phosphorylation

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