Abstract

Burns impact millions of individuals, both adults and children, across the globe, leading to significant morbidity and mortality rates. The primary factor influencing survival in burn cases is the speed of wound healing. Extensive wounds surpass the body’s natural healing abilities, and existing coverage materials often fall short due to limitations in cellular content, availability, or the risk of immunological rejection. Severe burns, particularly those that cover a substantial area of the body, continue to pose a significant challenge for contemporary medical practice. Current therapeutic approaches primarily involve skin grafting, which utilizes the patient’s own healthy tissue to facilitate wound coverage. In situations where the area affected by burns is extensive, it becomes nearly unfeasible to locate sufficient healthy skin for grafting. This challenge is further exacerbated by the presence of scarring, persistent pain, and various other complications that considerably diminish the quality of life for those who survive. Within this framework, a groundbreaking approach utilizing 3D bioprinting (3DBP) and stem cell cultivation may offer a viable solution for addressing severe burn injuries.

Keywords

burns, 3D bio printing, minimally invasive surgery, skin grafting, stem cell