Abstract

Microsomal epoxide hydrolase (mEH) is a significant enzyme for biotransformation which metabolizes the conversion of different structures and varieties of xenobiotics. And also the gene of microsomal epoxide hydrolase (EPHX1) is an evolutionarily substantially protected biotransformation enzyme that functions in the transformation of enzyme epoxides to diols. In addition to this information, the enzyme can detoxify and bioaccumulate a broad variety of epoxide substrates. Polymorphic variants and mutations and in the EPHX1 gene are related with the predisposition to a diverse of diseases in humans, including cancer. This review evaluated the function of EPHX1 in human pathology, particularly in terms of cancer risk.

Keywords

Biotransformation, human pathology, pro-carcinogenic molecules, smoking women, enzyme activity, biological equilibrium, Genetic polymorphism, environmental agents, polysaccharides, regional variations, xenobiotics detoxification, regional variations, asbestos, arsenic, chromium, nickel, radon, glutation-S-transferase