Abstract

Case report: Hereby we present a case study of a newborn with severe Transient Neonatal Myasthenia Gravis (TNMG). He had a maternal history of Myasthenia Gravis and the pregnancy was urgently terminated due to loss of fetal well-being. After birth, the newborn presented generalized hypotonia and apnea that required orotracheal intubation. Due to the maternal history and clinical picture, a diagnostic-therapeutic test was performed with intramuscular neostigmine with a transient improvement in respiratory effort. Intravenous immunoglobulin and pyridostigmine were administered, gradually presenting improvement in muscle tone until weaning from mechanical ventilation. Finally, he was discharged to intermediate therapy where he received rehabilitation.

Keywords

transient neonatal myasthenia gravis, congenital myasthenia gravis, neostigmine, pyridostigmine