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Non-alcoholic hepatic steatosis and its relation with metabolic syndrome

Gastroenterology & Hepatology: Open Access
Adaelle Dantas Ribeiro,<sup>1</sup> Eliara Orlando,<sup>1</sup> Ilária Ferreira Chaves,<sup>2</sup> João Marcos Costa de Siqueira,<sup>3</sup> Juliana de Lima Tavares,<sup>1</sup> Lázaro José Batista da Silva Mesquita,<sup>2</sup> Luís Michel Silva Lima,<sup>1</sup> Suévelem Patrícia Fedatto Granella,<sup>2</sup> Cleber Queiroz Leite,<sup>4</sup> Brian França dos Santos<sup>5</sup>

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Objective: The aim of this study is to investigate the relationship between Non-Alcoholic Hepatic Steatosis (NASH) and Metabolic Syndrome (MS).
Bibliographic review: NASH is a common liver condition in western industrialized countries, affecting individuals who do not consume alcohol. The pathogenesis of NASH involves environmental, genetic, and gut microbiota factors, and there is a strong association between NASH and MS, a condition that increases the risk of cardiovascular disease and type 2 diabetes. The relationship between NASH and MS is complex, with both
sharing features such as obesity, insulin resistance and inflammation. The study analyzed 13 articles and found a strong association between NASH and MS. Patients with NASH often have features of MS, including type 2 diabetes, obesity, and hypertension. Furthermore, the presence of MS is related to a higher risk of liver disease progression. The relationship between these conditions appears to be driven by factors such as elevated glucose, insulin resistance and increased visceral fat.
Final considerations: NASH and MS are conditions that pose significant public health challenges, especially in developed countries. The prevention and control of these conditions are closely linked to the promotion of lifestyle changes, including a healthy diet and physical exercise. These changes can have a positive impact on the incidence and progression of both NASH and MS, improving quality of life and reducing the risks associated with these pathological conditions. In addition, the importance of considering genetics and other individual factors in the evaluation and management of these multifactorial conditions is highlighted.


metabolic syndrome, obesity, non-alcoholic fatty liver disease