This review is purposed to highlight the potential of finding novel antibiotics by screening
various metabolites of actinomycetes. A significant global issue is drug-resistant bacteria
and fungi that cause infectious illnesses. The emergence of multi-drug resistant Salmonella
species have caused immense public health concern due to the resulting negative impacts.
Salmonella causes foodborne illnesses, which result in significant monetary loss and a
high death rate. The majority of Salmonella species are zoonotic infections, meaning they
can spread from animals to people when they consume tainted meat, animal products, or
other food items that have been contaminated with excrement from other animals. The
overuse of antibiotics in treating Salmonella infections has increased the urgency to search
for new potential sources of effective antibiotics. Actinomycetes are a group of bacteria
species found in soil that create vital biological products, primarily powerful antibiotics.
actinomycetes make up about two-thirds of all antibiotics, with Streptomyces species
producing the majority of them. Several studies have shown that there is an abundant
of potent antibiotics produced by actinomycetes. These bioactive compounds have been
extensively demonstrated to cause bactericidal and bacteriostatic activities. Thus, more
intensity should be put into unraveling more potential antibiotics from actinomycetes to
help reduce the burden of drug resistance.
actinomycetes, drug-resistant, antibiotics, Salmonella