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Infectious mononucleosis with leukemoid reaction, and systemic involvement

MOJ Clinical & Medical Case Reports
Lucía Leonor Cuevas López


Introduction: Epstein-Barr virus (EBV) infects more than 95% of the world’s population and is associated with infectious mononucleosis as well as a number of cancers in various geographical locations. It can usually cause tonsillitis, fever and adenomegaly, however it can present in severe forms with hematological alterations, with alterations in the bone marrow or with systemic alterations involving several apparatuses and systems.
Clinical case: We present the case of a 2-year-old female patient who developed a febrile respiratory condition and torpidly progressed to respiratory distress, tonsil hypertrophy obstruction, adenomegaly, hepatosplenomegaly, carditis, hematological alterations with leukemoid reaction.
Discussion/conclusion: Monoucleosis whose classic presentation is characterized by the presence of fever, pharyngitis and generalized lymphadenopathy, it is produced by the Epstein Barr virus, it has been called the kissing disease affecting adolescents and adults however it can occur in children being a picture beyond tonsillitis, we observe serious cases such as the one we will describe, we must carefully observe all the data that are presented and be able to integrate the diagnosis early.


lymphocytes, Epstein-Barr virus, leukemoid