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Effect of plant based diets and GK3 decoction in type 2 diabetes mellitus

Journal of Diabetes, Metabolic Disorders & Control
Ram Adhar Yadav, Amit Man Joshi, Sirjana Shrestha


Background: Numerous interventional studies have indicated that plant-based diets offer medical advantages, particularly in regulating glycemic levels, for individuals with type 2 diabetes mellitus (T2DM). Nonetheless, there have been no clinical trials conducted in context of Nepal, where reliance on plant-based foods is more common than in Western societies. This study aims to compare the impact of plant-based diets along with decoction of Guduchi (Tinospora cordifolia), Katuki (Neopicrorhiza scrophulariiflora), Khadira (Acacia catechu) and Kakamachi (Solanum nigrum), termed as GK3 decoction in patients diagnosed with T2DM among Nepalese population.
Materials and methods: Participants diagnosed with T2DM were intervened with plant based diets and GK3 decoction (n = 36) for a duration of 12 weeks. Glycosylated hemoglobulin (HbA1c), fasting plasma glucose (FBG), 2-h post-prandinal glucose (2-h PPG), complete blood count, lipid profile, renal function test, liver function test, c-reactive protein levels were measured at days 0, 30, and 120, with the primary study endpoint being the change in HbA1c levels over the 120 days.
Results: There was a statistically significant decrease of HbA1C levels of the participants by 9.0 % after intervention of plant based diets with GK3 decoction at week 12. Likewise, there was a statistically significant decrease in FBG, 2-h PPG, diastolic blood pressure and high-density lipoprotein cholesterol, hemoglobulin and red blood cell counts, but increase in triglyceride levels in the participants after the intervention at day 120 when compared with day 0.
Conclusion: Plant based diets with GK3 decoction was found to be effective for glycemic control among T2DM patients. However, there was onset of anemia in the participants after the intervention. Hence, the plant based diets with GK3 decoction to manage T2DM could not be recommended and further randomized controlled trials are warranted to confirm the study findings.


type 2 diabetes mellitus, plant-based diets, GK3 decoction, HbA1c, Nepal